Influence of the NAT2 gene polymorphic markers on the effectiveness and safety of treatment in patients with newly diagnosed pulmonary tuberculosis based on peripheral red blood cell dynamics

Background. Individual sensitivity to isoniazid in tuberculosis patients is determined by the presence of N-acetyltransferase 2 (NAT2) enzyme gene allelic variants genome. Evaluation quantitative and qualitative alterations peripheral blood can be used for diagnosis, disease severity estimation, or as a clue estimation anti-tuberculosis chemotherapy effectiveness safety. Aim: Find associations between acetylation type red cell (RBC) dynamics; determine effect NAT2 rate on safety treatment with newly identified pulmonary (TB) residing Sakha Republic (Yakutia). Methods. This study included 146 various clinical forms diagnosed TB. Oral isoniazid, rifampicin, pyrazinamide, ethambutol were administered patients. Genotyping was performed via real time PCR. Results. Rapid intermediate acetylators showed an increase hemoglobin concentrations RBC erythrocyte content end (P<0.05). Incidence anemia lower acetylators, compared rapid slow (P=0.013). Negative correlation established absolute count (P=0.017). Patients increased distribution width indexes RDW-CV RDW-SD Conclusions. An adequate therapeutic achieved standard doses anti-TB medications type. required medication dose correction. TB enables clinicians choose optimal medications, specifically, dose.